Francesco Bruni Selected Research

Polynucleotide Adenylyltransferase (Polymerase, Poly A)

1/2020	Biallelic Mutations in MTPAP Associated with a Lethal Encephalopathy.
12/2014	A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.

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Francesco Bruni Research Topics

Disease

4	Mitochondrial Diseases (Mitochondrial Disease) 01/2020 - 06/2014
2	Fever (Fevers) 01/2022 - 01/2015
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/2021 - 02/2012
2	Spastic Ataxia 01/2020 - 12/2014
2	Optic Atrophy 01/2020 - 12/2014
2	Endometriosis 02/2011 - 07/2010
1	COVID-19 05/2022
1	Hemorrhage 05/2022
1	Erectile Dysfunction 05/2022
1	Necrosis 05/2022
1	Priapism 05/2022
1	Retinitis 05/2022
1	Vitreous Hemorrhage 05/2022
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 05/2022
1	Adenomyosis 01/2022
1	Rectovaginal Fistula 01/2022
1	Complementation Group D1 Fanconi Anemia 09/2021
1	MELAS Syndrome (Syndrome, MELAS) 07/2021
1	Stroke (Strokes) 07/2021
1	Lactic Acidosis 07/2021
1	Mitochondrial encephalopathy 07/2021
1	Paresis (Hemiparesis) 01/2020
1	Late Onset Disorders 01/2020
1	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 01/2020
1	Hypersensitivity (Allergy) 01/2018
1	Muscle Hypotonia (Hypotonia) 01/2018
1	Cardiomyopathies (Cardiomyopathy) 01/2018
1	Spinocerebellar Ataxias (Spinocerebellar Ataxia) 01/2018
1	Seizures (Absence Seizure) 01/2018
1	Epilepsia Partialis Continua 01/2018
1	Ataxia (Dyssynergia) 01/2018
1	Epilepsy (Aura) 01/2018
1	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2015
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2015
1	Wounds and Injuries (Trauma) 01/2015
1	Arthralgia (Joint Pain) 01/2015
1	Glioblastoma (Glioblastoma Multiforme) 01/2009
1	Intraoperative Complications 09/2007

Drug/Important Bio-Agent (IBA)

3	Proteins (Proteins, Gene)FDA Link 09/2021 - 01/2018
3	EnzymesIBA 01/2018 - 01/2017
2	Polynucleotide Adenylyltransferase (Polymerase, Poly A)IBA 01/2020 - 12/2014
1	BNT162 VaccineIBA 05/2022
1	Antiviral Agents (Antivirals)IBA 05/2022
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 05/2022
1	Retinaldehyde (Retinal)IBA 05/2022
1	RNA (Ribonucleic Acid)IBA 05/2022
1	VaccinesIBA 05/2022
1	Fluorescein (Funduscein)FDA LinkGeneric 05/2022
1	Flavin-Adenine Dinucleotide (FAD)IBA 09/2021
1	Messenger RNA (mRNA)IBA 09/2021
1	3' Untranslated Regions (3' UTR)IBA 09/2021
1	Leu Transfer RNAIBA 07/2021
1	GMP ReductaseIBA 01/2020
1	Mitochondrial DNA (mtDNA)IBA 01/2020
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	Ligases (Synthetase)IBA 01/2018
1	tyrosyl-DNA phosphodiesteraseIBA 01/2018
1	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2018
1	Transfer RNA (tRNA)IBA 01/2018
1	Valine-tRNA LigaseIBA 01/2018
1	Carrier Proteins (Binding Protein)IBA 01/2018
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2018
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2018
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 01/2018
1	Immunoglobulins (Immunoglobulin)IBA 01/2015
1	DefensinsIBA 01/2015
1	Uremic ToxinsIBA 01/2015
1	Biomarkers (Surrogate Marker)IBA 01/2015
1	AntigensIBA 01/2015
1	ProteomeIBA 06/2014
1	Formaldehyde (Formol)FDA Link 07/2010
1	2,5-dichloro-4-bromophenol (B 2)IBA 09/2007

Therapy/Procedure

4	Hysterectomy 01/2022 - 01/2009
1	Drug Therapy (Chemotherapy) 05/2022
1	Blood Transfusion (Blood Transfusions) 01/2022
1	Lymph Node Excision (Lymph Node Dissection) 01/2021
1	Aftercare (After-Treatment) 01/2015
1	Hemodiafiltration 01/2015
1	Therapeutics 02/2011